4KB6
Structure of porcine cyclic GMP AMP synthase (CGAS) in complex with DNA, ATP and GTP
Summary for 4KB6
Entry DOI | 10.2210/pdb4kb6/pdb |
Related | 4JLX 4JLZ |
Descriptor | Uncharacterized protein, DNA (5'-D(P*CP*GP*AP*CP*GP*CP*TP*AP*GP*CP*GP*TP*CP*G)-3'), ZINC ION, ... (7 entities in total) |
Functional Keywords | oas-like fold, receptor, immunity, cgas, double stranded dna, gtp, cytosol, transferase-dna complex, transferase/dna |
Biological source | Sus scrofa (pigs,swine,wild boar) More |
Cellular location | Cytoplasm, cytosol : I3LM39 |
Total number of polymer chains | 3 |
Total formula weight | 52153.82 |
Authors | Deimling, T.,Hopfner, K.-P. (deposition date: 2013-04-23, release date: 2013-06-05, Last modification date: 2023-09-20) |
Primary citation | Civril, F.,Deimling, T.,de Oliveira Mann, C.C.,Ablasser, A.,Moldt, M.,Witte, G.,Hornung, V.,Hopfner, K.P. Structural mechanism of cytosolic DNA sensing by cGAS. Nature, 498:332-337, 2013 Cited by PubMed: 23722159DOI: 10.1038/nature12305 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.0754 Å) |
Structure validation
Download full validation report