4K9W

Complex of human CYP3A4 with a desoxyritonavir analog

Summary for 4K9W

Entry DOI	10.2210/pdb4k9w/pdb
Related	4I4G 4I4H 4K9T 4K9U 4K9V 4K9X
Descriptor	Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, N~2~-(methyl{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}carbamoyl)-N-[(2R,5S)-1-phenyl-5-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}octan-2-yl]-L-valinamide, ... (4 entities in total)
Functional Keywords	cytochrome p450 3a4, alpha-beta protein, cytochrome p450 fold, monooxygenase, cytochrome p450 reductase, endoplasmic reticulum, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane; Single-pass membrane protein: P08684
Total number of polymer chains	4
Total formula weight	228124.80
Authors	Sevrioukova, I.F.,Poulos, T.L. (deposition date: 2013-04-21, release date: 2013-06-19, Last modification date: 2023-09-20)
Primary citation	Sevrioukova, I.F.,Poulos, T.L. Dissecting Cytochrome P450 3A4-Ligand Interactions Using Ritonavir Analogues. Biochemistry, 52:4474-4481, 2013 Cited by PubMed: 23746300 DOI: 10.1021/bi4005396 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.399 Å)

Structure validation