4K8U
Crystal structure of TRAF4 TRAF domain
Summary for 4K8U
| Entry DOI | 10.2210/pdb4k8u/pdb |
| Descriptor | TNF receptor-associated factor 4 (2 entities in total) |
| Functional Keywords | traf domain, traf fold, protein interaction, signaling molecule binding, signaling protein |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 3 |
| Total formula weight | 68492.59 |
| Authors | Park, H.H.,Yoon, J.H. (deposition date: 2013-04-18, release date: 2014-01-15, Last modification date: 2024-03-20) |
| Primary citation | Yoon, J.H.,Cho, Y.J.,Park, H.H. Structure of the TRAF4 TRAF domain with a coiled-coil domain and its implications for the TRAF4 signalling pathway. Acta Crystallogr.,Sect.D, 70:2-10, 2014 Cited by PubMed Abstract: The TNF receptor-associated factor (TRAF) proteins are structurally similar scaffold proteins that mediate between members of the TNF receptor (TNFR) family and downstream effector molecules such as kinases in the immune signalling pathway. Seven TRAFs have been identified, including TRAF4, which is a unique member that participates in many ontogenic processes, including nerve-system development. TRAFs commonly contain the TRAF domain, which mediates interaction with target receptors and effectors. As a first step towards elucidating the molecular mechanisms of the TRAF4-mediated signalling pathway, the first crystal structure of the human TRAF4 TRAF domain with a coiled-coil domain is reported at 2.3 Å resolution. PubMed: 24419373DOI: 10.1107/S139900471302333X PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.302 Å) |
Structure validation
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