4K77
JAK1 kinase (JH1 domain) in complex with compound 6
Summary for 4K77
| Entry DOI | 10.2210/pdb4k77/pdb |
| Descriptor | Tyrosine-protein kinase JAK1, 4-(cyclohexylamino)pyrido[3,4-d]pyrimidin-8(7H)-one (3 entities in total) |
| Functional Keywords | protein kinase, phosphotransfer, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Endomembrane system; Peripheral membrane protein: P23458 |
| Total number of polymer chains | 2 |
| Total formula weight | 69981.77 |
| Authors | Eigenbrot, C.,Shia, S. (deposition date: 2013-04-16, release date: 2013-10-02, Last modification date: 2023-12-06) |
| Primary citation | Labadie, S.,Barrett, K.,Blair, W.S.,Chang, C.,Deshmukh, G.,Eigenbrot, C.,Gibbons, P.,Johnson, A.,Kenny, J.R.,Kohli, P.B.,Liimatta, M.,Lupardus, P.J.,Shia, S.,Steffek, M.,Ubhayakar, S.,Abbema, A.V.,Zak, M. Design and evaluation of novel 8-oxo-pyridopyrimidine Jak1/2 inhibitors. Bioorg.Med.Chem.Lett., 23:5923-5930, 2013 Cited by PubMed: 24042009DOI: 10.1016/j.bmcl.2013.08.082 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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