4K5L
Phosphonic Arginine Mimetics as Inhibitors of the M1 Aminopeptidases from Plasmodium falciparum
Summary for 4K5L
Entry DOI | 10.2210/pdb4k5l/pdb |
Related | 4K3N 4K5M 4K5N 4K5O 4K5P |
Descriptor | M1 family aminopeptidase, ZINC ION, [(1R)-1-amino-5-carbamimidamidopentyl]phosphonic acid, ... (5 entities in total) |
Functional Keywords | m1 alanyl-aminopeptidase, protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Plasmodium falciparum FcB1/Columbia |
Cellular location | Cytoplasm: O96935 |
Total number of polymer chains | 1 |
Total formula weight | 105147.88 |
Authors | McGowan, S. (deposition date: 2013-04-14, release date: 2013-06-12, Last modification date: 2023-09-20) |
Primary citation | Kannan Sivaraman, K.,Paiardini, A.,Sienczyk, M.,Ruggeri, C.,Oellig, C.A.,Dalton, J.P.,Scammells, P.J.,Drag, M.,McGowan, S. Synthesis and Structure-Activity Relationships of Phosphonic Arginine Mimetics as Inhibitors of the M1 and M17 Aminopeptidases from Plasmodium falciparum. J.Med.Chem., 56:5213-5217, 2013 Cited by PubMed: 23713488DOI: 10.1021/jm4005972 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.91 Å) |
Structure validation
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