4K26
4,4-Dioxo-5,6-dihydro-[1,4,3]oxathiazines, a novel class of 11 -HSD1 inhibitors for the treatment of diabetes
Summary for 4K26
Entry DOI | 10.2210/pdb4k26/pdb |
Related | 4K1L |
Descriptor | Corticosteroid 11-beta-dehydrogenase isozyme 1, (4aS,8aR)-N-cyclohexyl-4a,5,6,7,8,8a-hexahydro-4,1,2-benzoxathiazin-3-amine 1,1-dioxide, SULFATE ION, ... (5 entities in total) |
Functional Keywords | oxidoreductase, alpha and beta proteins, nad(p)-binding rossman-fold, short chain dehydrogenase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Mus musculus (mouse) |
Cellular location | Endoplasmic reticulum membrane; Single-pass type II membrane protein: P50172 |
Total number of polymer chains | 2 |
Total formula weight | 63523.17 |
Authors | Loenze, P.,Schimanski-Breves, S.,Vonderheyden, C.,Engel, C.K. (deposition date: 2013-04-08, release date: 2014-04-09, Last modification date: 2023-09-20) |
Primary citation | Bohme, T.,Engel, C.K.,Farjot, G.,Gussregen, S.,Haack, T.,Tschank, G.,Ritter, K. 1,1-Dioxo-5,6-dihydro-[4,1,2]oxathiazines, a novel class of 11-HSD1 inhibitors for the treatment of diabetes. Bioorg.Med.Chem.Lett., 23:4685-4691, 2013 Cited by PubMed: 23845218DOI: 10.1016/j.bmcl.2013.05.102 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.21 Å) |
Structure validation
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