4K18

Structure of PIM-1 kinase bound to 5-(4-cyanobenzyl)-N-(4-fluorophenyl)-7-hydroxypyrazolo[1,5-a]pyrimidine-3-carboxamide

Summary for 4K18

Entry DOI	10.2210/pdb4k18/pdb
Related	4K0Y 4K1B
Descriptor	Serine/threonine-protein kinase pim-1, PHOSPHATE ION, 5-(4-cyanobenzyl)-N-(4-fluorophenyl)-7-hydroxypyrazolo[1,5-a]pyrimidine-3-carboxamide, ... (4 entities in total)
Functional Keywords	pim-1, kinase domain, ser/thr kinase, atp-competitive, structure-based drug design, phosphorylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
Total number of polymer chains	1
Total formula weight	32416.56
Authors	Murray, J.M.,Wallweber, H.,Steffek, M. (deposition date: 2013-04-04, release date: 2013-05-15, Last modification date: 2024-02-28)
Primary citation	Wang, X.,Magnuson, S.,Pastor, R.,Fan, E.,Hu, H.,Tsui, V.,Deng, W.,Murray, J.,Steffek, M.,Wallweber, H.,Moffat, J.,Drummond, J.,Chan, G.,Harstad, E.,Ebens, A.J. Discovery of novel pyrazolo[1,5-a]pyrimidines as potent pan-Pim inhibitors by structure- and property-based drug design. Bioorg.Med.Chem.Lett., 23:3149-3153, 2013 Cited by PubMed: 23623490 DOI: 10.1016/j.bmcl.2013.04.020 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.051 Å)

Structure validation