4JZX

Crystal Structure of Leshmaniasis major Farnesyl diphosphate synthase in complex with 3-BUTYL-1-(2,2-DIPHOSPHONOETHYL)PYRIDINIUM, IPP and Ca2+

4JZX の概要

• エントリーDOI: 10.2210/pdb4jzx/pdb
• 関連するPDBエントリー: 4JZB 4K10
• 分子名称: Farnesyl pyrophosphate synthase, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, 3-butyl-1-(2,2-diphosphonoethyl)pyridinium, ... (5 entities in total)
• 機能のキーワード: geranyl transferase, fpps, farnesyl pyrophosphate synthase, farnesyl diphosphate synthase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Leishmania major
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 83471.51

構造登録者

Aripirala, S.,Gabelli, S.,Amzel, L.M. (登録日: 2013-04-03, 公開日: 2014-03-05, 最終更新日: 2017-11-15)

• 主引用文献: Aripirala, S.,Gonzalez-Pacanowska, D.,Oldfield, E.,Kaiser, M.,Amzel, L.M.,Gabelli, S.B.; Structural and thermodynamic basis of the inhibition of Leishmania major farnesyl diphosphate synthase by nitrogen-containing bisphosphonates.; Acta Crystallogr.,Sect.D, 70:802-810, 2014; PubMed: 24598749; DOI: 10.1107/S1399004713033221

実験手法

X-RAY DIFFRACTION (1.8 Å)