4JZR
Structure of Prolyl Hydroxylase Domain-containing Protein (PHD) with Inhibitors
Summary for 4JZR
Entry DOI | 10.2210/pdb4jzr/pdb |
Descriptor | Egl nine homolog 1, NICKEL (II) ION, 2-(biphenyl-4-yl)-8-[(1-methyl-1H-imidazol-2-yl)methyl]-2,8-diazaspiro[4.5]decan-1-one, ... (5 entities in total) |
Functional Keywords | prolyl hydroxylase, oxidoreductase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q9GZT9 |
Total number of polymer chains | 1 |
Total formula weight | 24751.79 |
Authors | |
Primary citation | Deng, G.,Zhao, B.,Ma, Y.,Xu, Q.,Wang, H.,Yang, L.,Zhang, Q.,Guo, T.B.,Zhang, W.,Jiao, Y.,Cai, X.,Zhang, J.,Liu, H.,Guan, X.,Lu, H.,Xiang, J.,Elliott, J.D.,Lin, X.,Ren, F. Novel complex crystal structure of prolyl hydroxylase domain-containing protein 2 (PHD2): 2,8-Diazaspiro[4.5]decan-1-ones as potent, orally bioavailable PHD2 inhibitors Bioorg.Med.Chem., 21:6349-6358, 2013 Cited by PubMed: 24055079DOI: 10.1016/j.bmc.2013.08.046 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
Download full validation report