4JZR
Structure of Prolyl Hydroxylase Domain-containing Protein (PHD) with Inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Egl nine homolog 1 | polymer | 216 | 24230.5 | 1 | UniProt (Q9GZT9) Pfam (PF13640) | Homo sapiens (human) | Hypoxia-inducible factor prolyl hydroxylase 2, HIF-PH2, HIF-prolyl hydroxylase 2, HPH-2, Prolyl hydroxylase domain-containing protein 2, PHD2, SM-20 |
| 2 | B (A) | NICKEL (II) ION | non-polymer | 58.7 | 1 | Chemie (NI) | |||
| 3 | C (A) | 2-(biphenyl-4-yl)-8-[(1-methyl-1H-imidazol-2-yl)methyl]-2,8-diazaspiro[4.5]decan-1-one | non-polymer | 400.5 | 1 | Chemie (4JR) | |||
| 4 | D (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 5 | E (A) | water | water | 18.0 | 49 | Chemie (HOH) |
Sequence modifications
A: 189 - 399 (UniProt: Q9GZT9)
| PDB | External Database | Details |
|---|---|---|
| Gly 184 | - | expression tag |
| Ser 185 | - | expression tag |
| Phe 186 | - | expression tag |
| Thr 187 | - | expression tag |
| Met 188 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 24230.5 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 521.3 | |
| All* | Total formula weight | 24751.8 |
