4JZJ

Crystal Structure of Receptor-Fab Complex

Summary for 4JZJ

DescriptorInterleukin-3 receptor subunit alpha, Fab Heavy Chain, Fab Light Chain, ... (10 entities in total)
Functional Keywordsreceptor-fab complex, cytokine receptor-immune system complex, cytokine receptor/immune system
Biological sourceHomo sapiens (human)
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Cellular locationMembrane; Single-pass type I membrane protein P26951
Total number of polymer chains6
Total molecular weight165746.39
Authors
Broughton, S.E.,Parker, M.W. (deposition date: 2013-04-03, release date: 2014-04-09, Last modification date: 2017-11-15)
Primary citation
Broughton, S.E.,Hercus, T.R.,Hardy, M.P.,McClure, B.J.,Nero, T.L.,Dottore, M.,Huynh, H.,Braley, H.,Barry, E.F.,Kan, W.L.,Dhagat, U.,Scotney, P.,Hartman, D.,Busfield, S.J.,Owczarek, C.M.,Nash, A.D.,Wilson, N.J.,Parker, M.W.,Lopez, A.F.
Dual mechanism of interleukin-3 receptor blockade by an anti-cancer antibody
Cell Rep, 8:410-419, 2014
PubMed: 25043189 (PDB entries with the same primary citation)
DOI: 10.1016/j.celrep.2014.06.038
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.801 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.24480.6%6.6%5.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution