4JZJ
Crystal Structure of Receptor-Fab Complex
Summary for 4JZJ
Entry DOI | 10.2210/pdb4jzj/pdb |
Descriptor | Interleukin-3 receptor subunit alpha, Fab Heavy Chain, Fab Light Chain, ... (9 entities in total) |
Functional Keywords | receptor-fab complex, cytokine receptor-immune system complex, cytokine receptor/immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Membrane; Single-pass type I membrane protein: P26951 |
Total number of polymer chains | 6 |
Total formula weight | 165530.21 |
Authors | Broughton, S.E.,Parker, M.W. (deposition date: 2013-04-03, release date: 2014-04-09, Last modification date: 2020-07-29) |
Primary citation | Broughton, S.E.,Hercus, T.R.,Hardy, M.P.,McClure, B.J.,Nero, T.L.,Dottore, M.,Huynh, H.,Braley, H.,Barry, E.F.,Kan, W.L.,Dhagat, U.,Scotney, P.,Hartman, D.,Busfield, S.J.,Owczarek, C.M.,Nash, A.D.,Wilson, N.J.,Parker, M.W.,Lopez, A.F. Dual mechanism of interleukin-3 receptor blockade by an anti-cancer antibody Cell Rep, 8:410-419, 2014 Cited by PubMed: 25043189DOI: 10.1016/j.celrep.2014.06.038 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.801 Å) |
Structure validation
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