4JZI
Crystal Structure of Matriptase in complex with Inhibitor".
Summary for 4JZI
| Entry DOI | 10.2210/pdb4jzi/pdb |
| Related | 4JYT 4JZ1 |
| Descriptor | Suppressor of tumorigenicity 14 protein, N-(trans-4-aminocyclohexyl)-2,6-bis(4-carbamimidoylphenoxy)pyridine-4-carboxamide (3 entities in total) |
| Functional Keywords | matriptase, inhibitor, complex structure, hydrolase |
| Biological source | Homo sapiens (human) |
| Cellular location | Membrane ; Single-pass type II membrane protein : Q9Y5Y6 |
| Total number of polymer chains | 1 |
| Total formula weight | 26951.31 |
| Authors | Subramanya, H.S.,Chandra, R.B.,Ashok, K.N.,Chakshusmathi, G.,Ramesh, K.S. (deposition date: 2013-04-03, release date: 2014-02-26, Last modification date: 2023-11-08) |
| Primary citation | Goswami, R.,Mukherjee, S.,Wohlfahrt, G.,Ghadiyaram, C.,Nagaraj, J.,Chandra, B.R.,Sistla, R.K.,Satyam, L.K.,Samiulla, D.S.,Moilanen, A.,Subramanya, H.S.,Ramachandra, M. Discovery of Pyridyl Bis(oxy)dibenzimidamide Derivatives as Selective Matriptase Inhibitors ACS MED.CHEM.LETT., 4:1152-1157, 2013 Cited by PubMed: 24900621DOI: 10.1021/ml400213v PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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