4JZD

Structure of factor VIIA in complex with the inhibitor 2-{2-[(4-carbamimidoylphenyl)carbamoyl]-6-methoxypyridin-3-yl}-5-{[(2S)-1-hydroxy-3,3-dimethylbutan-2-yl]carbamoyl}benzoic acid

4JZD の概要

• エントリーDOI: 10.2210/pdb4jzd/pdb
• 関連するPDBエントリー: 4JZE 4JZF
• 分子名称: Factor VIIa (Heavy Chain), Factor VIIa (Light Chain), 2-{2-[(4-carbamimidoylphenyl)carbamoyl]-6-methoxypyridin-3-yl}-5-{[(2S)-1-hydroxy-3,3-dimethylbutan-2-yl]carbamoyl}benzoic acid, ... (7 entities in total)
• 機能のキーワード: glycoprotein, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium binding, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: P08709 P08709
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 35909.78

構造登録者

Jacobson, B.L.,Anumula, R. (登録日: 2013-04-02, 公開日: 2013-08-21, 最終更新日: 2023-09-20)

• 主引用文献: Bolton, S.A.,Sutton, J.C.,Anumula, R.,Bisacchi, G.S.,Jacobson, B.,Slusarchyk, W.A.,Treuner, U.D.,Wu, S.C.,Zhao, G.,Pi, Z.,Sheriff, S.,Smirk, R.A.,Bisaha, S.,Cheney, D.L.,Wei, A.,Schumacher, W.A.,Hartl, K.S.,Liu, E.,Zahler, R.,Seiler, S.M.; Discovery of nonbenzamidine factor VIIa inhibitors using a biaryl acid scaffold.; Bioorg.Med.Chem.Lett., 23:5239-5243, 2013; PubMed: 23927973; DOI: 10.1016/j.bmcl.2013.06.028

実験手法

X-RAY DIFFRACTION (2.2 Å)