4JZ1

Crystal Structure of Matriptase in complex with Inhibitor

4JZ1 の概要

• エントリーDOI: 10.2210/pdb4jz1/pdb
• 関連するPDBエントリー: 4JYT 4JZI
• 分子名称: Suppressor of tumorigenicity 14 protein, 4,4'-[(3-{[(4-fluorophenyl)sulfonyl]amino}pyridine-2,6-diyl)bis(oxy)]dibenzenecarboximidamide (3 entities in total)
• 機能のキーワード: matriptase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane ; Single-pass type II membrane protein : Q9Y5Y6
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 26984.29

構造登録者

Subramanya, H.S.,Ravi, B.C.,Ashok, K.N.,Chakshusmathi, G.,Ramesh, K.S. (登録日: 2013-04-02, 公開日: 2014-02-26, 最終更新日: 2023-11-08)

• 主引用文献: Goswami, R.,Mukherjee, S.,Wohlfahrt, G.,Ghadiyaram, C.,Nagaraj, J.,Chandra, B.R.,Sistla, R.K.,Satyam, L.K.,Samiulla, D.S.,Moilanen, A.,Subramanya, H.S.,Ramachandra, M.; Discovery of Pyridyl Bis(oxy)dibenzimidamide Derivatives as Selective Matriptase Inhibitors; ACS MED.CHEM.LETT., 4:1152-1157, 2013; PubMed: 24900621; DOI: 10.1021/ml400213v

実験手法

X-RAY DIFFRACTION (1.9 Å)