4JX7

Crystal structure of Pim1 kinase in complex with inhibitor 2-[(trans-4-aminocyclohexyl)amino]-4-{[3-(trifluoromethyl)phenyl]amino}pyrido[4,3-d]pyrimidin-5(6H)-one

4JX7 の概要

• エントリーDOI: 10.2210/pdb4jx7/pdb
• 関連するPDBエントリー: 4JX3
• 分子名称: Serine/threonine-protein kinase pim-1, PIM1 consensus peptide, 2-[(trans-4-aminocyclohexyl)amino]-4-{[3-(trifluoromethyl)phenyl]amino}pyrido[4,3-d]pyrimidin-5(6H)-one, ... (4 entities in total)
• 機能のキーワード: serine/threonine-protein kinases, atp binding, phosphorylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 39304.68

構造登録者

Lee, S.J.,Han, B.G.,Cho, J.W.,Choi, J.S.,Lee, J.K.,Song, H.J.,Koh, J.S.,Lee, B.I. (登録日: 2013-03-27, 公開日: 2013-08-28, 最終更新日: 2023-09-20)

• 主引用文献: Lee, S.J.,Han, B.G.,Cho, J.W.,Choi, J.S.,Lee, J.,Song, H.J.,Koh, J.S.,Lee, B.I.; Crystal structure of pim1 kinase in complex with a pyrido[4,3-d]pyrimidine derivative suggests a unique binding mode.; Plos One, 8:e70358-e70358, 2013; PubMed: 23936194; DOI: 10.1371/journal.pone.0070358

実験手法

X-RAY DIFFRACTION (2.4 Å)