4JVV

Crystal structure of the evolved variant of the computationally designed serine hydrolase, OSH55.4_H1, covalently bound with diisopropyl fluorophosphate (DFP), Northeast Structural Genomics Consortium (NESG) Target OR273

Summary for 4JVV

Entry DOI	10.2210/pdb4jvv/pdb
Descriptor	evolved variant of the computationally designed serine hydrolase (2 entities in total)
Functional Keywords	structural genomics, psi-biology, protein structure initiative, northeast structural genomics consortium (nesg) target or273, diisopropyl fluorophosphate, osh55.4_h1, unknown function
Biological source	synthetic construct
Total number of polymer chains	1
Total formula weight	16995.00
Authors	Kuzin, A.,Lew, S.,Rajagopalan, S.,Seetharaman, J.,Tong, S.,Everett, J.K.,Acton, T.B.,Baker, D.,Montelione, G.T.,Tong, L.,Hunt, J.F.,Northeast Structural Genomics Consortium (NESG) (deposition date: 2013-03-26, release date: 2013-04-24, Last modification date: 2023-12-06)
Primary citation	Rajagopalan, S.,Wang, C.,Yu, K.,Kuzin, A.P.,Richter, F.,Lew, S.,Miklos, A.E.,Matthews, M.L.,Seetharaman, J.,Su, M.,Hunt, J.F.,Cravatt, B.F.,Baker, D. Design of activated serine-containing catalytic triads with atomic-level accuracy. Nat.Chem.Biol., 10:386-391, 2014 Cited by PubMed: 24705591 DOI: 10.1038/nchembio.1498 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.288 Å)

Structure validation