4JVF

The Crystal structure of PDE6D in complex with the inhibitor (s)-5

4JVF の概要

• エントリーDOI: 10.2210/pdb4jvf/pdb
• 関連するPDBエントリー: 4JV6 4JV8 4JVB
• 分子名称: Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, (2S)-2-(2-phenyl-1H-benzimidazol-1-yl)-2-(piperidin-4-yl)ethyl 1-(1-benzyl-1H-benzimidazol-2-yl)piperidine-4-carboxylate (3 entities in total)
• 機能のキーワード: immunoglobulin-like beta-sandwich, gdi-like solubilizing factor, prenyl binding, protein binding-inhibitor complex, protein binding/inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm, cytosol : O43924
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 18223.92

構造登録者

Gunther, Z.,Papke, B.,Ismail, S.,Vartak, N.,Chandra, A.,Hoffmann, M.,Hahn, S.,Triola, G.,Wittinghofer, A.,Bastiaens, P.,Waldmann, H. (登録日: 2013-03-25, 公開日: 2013-05-22, 最終更新日: 2023-09-20)

• 主引用文献: Zimmermann, G.,Papke, B.,Ismail, S.,Vartak, N.,Chandra, A.,Hoffmann, M.,Hahn, S.A.,Triola, G.,Wittinghofer, A.,Bastiaens, P.I.,Waldmann, H.; Small molecule inhibition of the KRAS PDEd interaction impairs oncogenic KRAS signalling; Nature, 497:638-642, 2013; PubMed: 23698361; DOI: 10.1038/nature12205

実験手法

X-RAY DIFFRACTION (2.4 Å)