4JT8

Crystal Structure of human SIRT3 with ELT inhibitor 28 [4-(4-{2-[(2,2-dimethylpropanoyl)amino]ethyl}piperidin-1-yl)thieno[3,2-d]pyrimidine-6-carboxamide[

Summary for 4JT8

Entry DOI	10.2210/pdb4jt8/pdb
Related	4JSR 4JT9
Descriptor	NAD-dependent protein deacetylase sirtuin-3, mitochondrial, ZINC ION, 4-(4-{2-[(2,2-dimethylpropanoyl)amino]ethyl}piperidin-1-yl)thieno[3,2-d]pyrimidine-6-carboxamide, ... (4 entities in total)
Functional Keywords	deacetylase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Mitochondrion matrix: Q9NTG7
Total number of polymer chains	1
Total formula weight	32067.27
Authors	Dai, H. (deposition date: 2013-03-22, release date: 2013-04-24, Last modification date: 2024-02-28)
Primary citation	Disch, J.S.,Evindar, G.,Chiu, C.H.,Blum, C.A.,Dai, H.,Jin, L.,Schuman, E.,Lind, K.E.,Belyanskaya, S.L.,Deng, J.,Coppo, F.,Aquilani, L.,Graybill, T.L.,Cuozzo, J.W.,Lavu, S.,Mao, C.,Vlasuk, G.P.,Perni, R.B. Discovery of Thieno[3,2-d]pyrimidine-6-carboxamides as Potent Inhibitors of SIRT1, SIRT2, and SIRT3. J.Med.Chem., 56:3666-3679, 2013 Cited by PubMed: 23570514 DOI: 10.1021/jm400204k PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.26 Å)

Structure validation