4JSF

Structure of rat neuronal nitric oxide synthase heme domain in complex with 6,6'-(heptane-1,7-diyl)bis(4-methylpyridin-2-amine)

Summary for 4JSF

Entry DOI	10.2210/pdb4jsf/pdb
Related	4JSE 4JSG 4JSH 4JSI 4JSJ 4JSK 4JSL 4JSM
Descriptor	Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total)
Functional Keywords	nitric oxide synthase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Rattus norvegicus (rat)
Cellular location	Cell membrane, sarcolemma ; Peripheral membrane protein : P29476
Total number of polymer chains	2
Total formula weight	100148.92
Authors	Li, H.,Poulos, T.L. (deposition date: 2013-03-22, release date: 2013-08-07, Last modification date: 2023-09-20)
Primary citation	Jing, Q.,Li, H.,Fang, J.,Roman, L.J.,Martasek, P.,Poulos, T.L.,Silverman, R.B. In search of potent and selective inhibitors of neuronal nitric oxide synthase with more simple structures. Bioorg.Med.Chem., 21:5323-5331, 2013 Cited by PubMed: 23867386 DOI: 10.1016/j.bmc.2013.06.014 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation