4JRG

The 1.9A crystal structure of humanized Xenopus MDM2 with RO5313109 - a pyrrolidine MDM2 inhibitor

4JRG の概要

• エントリーDOI: 10.2210/pdb4jrg/pdb
• 関連するPDBエントリー: 4IPF
• 分子名称: E3 ubiquitin-protein ligase Mdm2, (3R,4R,5S)-3-(3-chlorophenyl)-4-(4-chlorophenyl)-4-cyano-N-[(3S)-3,4-dihydroxybutyl]-5-(2,2-dimethylpropyl)-D-prolinamide (3 entities in total)
• 機能のキーワード: protein-inhibitor complex, pyrrolidine, e3 ubiquitin ligase, p53, nucleus, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• 由来する生物種: Xenopus laevis (clawed frog,common platanna,platanna)
• 細胞内の位置: Nucleus, nucleoplasm (By similarity): P56273
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 20699.79

構造登録者

Graves, B.J.,Janson, C.A.,Lukacs, C. (登録日: 2013-03-21, 公開日: 2013-07-24, 最終更新日: 2024-02-28)

• 主引用文献: Ding, Q.,Zhang, Z.,Liu, J.J.,Jiang, N.,Zhang, J.,Ross, T.M.,Chu, X.J.,Bartkovitz, D.,Podlaski, F.,Janson, C.,Tovar, C.,Filipovic, Z.M.,Higgins, B.,Glenn, K.,Packman, K.,Vassilev, L.T.,Graves, B.; Discovery of RG7388, a Potent and Selective p53-MDM2 Inhibitor in Clinical Development.; J.Med.Chem., 56:5979-5983, 2013; PubMed: 23808545; DOI: 10.1021/jm400487c

実験手法

X-RAY DIFFRACTION (1.9 Å)