4JRA
CRYSTAL STRUCTURE OF THE BOTULINUM NEUROTOXIN A RECEPTOR-BINDING DOMAIN IN COMPLEX WITH THE LUMINAL DOMAIN Of SV2C
Summary for 4JRA
| Entry DOI | 10.2210/pdb4jra/pdb |
| Descriptor | Botulinum neurotoxin type A, Synaptic vesicle glycoprotein 2C, CHLORIDE ION, ... (5 entities in total) |
| Functional Keywords | beta-helix, vesicles, lumen, toxin, hydrolase |
| Biological source | Clostridium botulinum More |
| Cellular location | Botulinum neurotoxin A light chain: Secreted. Botulinum neurotoxin A heavy chain: Secreted: P10845 Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein (By similarity): Q496J9 |
| Total number of polymer chains | 4 |
| Total formula weight | 135677.72 |
| Authors | Benoit, R.M.,Frey, D.,Wieser, M.M.,Jaussi, R.,Schertler, G.F.X.,Capitani, G.,Kammerer, R.A. (deposition date: 2013-03-21, release date: 2013-11-20, Last modification date: 2023-09-20) |
| Primary citation | Benoit, R.M.,Frey, D.,Hilbert, M.,Kevenaar, J.T.,Wieser, M.M.,Stirnimann, C.U.,McMillan, D.,Ceska, T.,Lebon, F.,Jaussi, R.,Steinmetz, M.O.,Schertler, G.F.,Hoogenraad, C.C.,Capitani, G.,Kammerer, R.A. Structural basis for recognition of synaptic vesicle protein 2C by botulinum neurotoxin A. Nature, 505:108-111, 2014 Cited by PubMed: 24240280DOI: 10.1038/nature12732 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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