4JR5

Structure-based Identification of Ureas as Novel Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors

4JR5 の概要

• エントリーDOI: 10.2210/pdb4jr5/pdb
• 関連するPDBエントリー: 4JNM 4KFN 4KFO
• 分子名称: Nicotinamide phosphoribosyltransferase, 1-[4-(piperidin-1-ylsulfonyl)phenyl]-3-(pyridin-3-ylmethyl)thiourea, PHOSPHATE ION, ... (5 entities in total)
• 機能のキーワード: transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm (By similarity): P43490
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 115169.82

構造登録者

Zheng, X.,Bauer, P.,Baumeister, T.,Buckmelter, A.J.,Caligiuri, M.,Clodfelter, K.H.,Han, B.,Ho, Y.,Kley, N.,Lin, J.,Reynolds, D.J.,Sharma, G.,Smith, C.C.,Wang, Z.,Dragovich, P.S.,Oh, A.,Wang, W.,Zak, M.,Gunzner-Toste, J.,Zhao, G.,Yuen, P.,Bair, K.W. (登録日: 2013-03-21, 公開日: 2013-05-08, 最終更新日: 2024-02-28)

• 主引用文献: Zheng, X.,Bauer, P.,Baumeister, T.,Buckmelter, A.J.,Caligiuri, M.,Clodfelter, K.H.,Han, B.,Ho, Y.C.,Kley, N.,Lin, J.,Reynolds, D.J.,Sharma, G.,Smith, C.C.,Wang, Z.,Dragovich, P.S.,Oh, A.,Wang, W.,Zak, M.,Gunzner-Toste, J.,Zhao, G.,Yuen, P.W.,Bair, K.W.; Structure-based identification of ureas as novel nicotinamide phosphoribosyltransferase (nampt) inhibitors.; J.Med.Chem., 56:4921-4937, 2013; PubMed: 23617784; DOI: 10.1021/jm400186h

実験手法

X-RAY DIFFRACTION (1.906 Å)