4JQW

Crystal Structure of a Complex of NOD1 CARD and Ubiquitin

4JQW の概要

• エントリーDOI: 10.2210/pdb4jqw/pdb
• 関連するPDBエントリー: 1AAR 1UBQ 2NSN 2NZ7 2O6V 4E9M
• 分子名称: Nucleotide-binding oligomerization domain-containing protein 1, Polyubiquitin-C, PHOSPHATE ION (3 entities in total)
• 機能のキーワード: death domain-like fold, innate immunity, rip2, atg16l, s-dimethylarsenic, apoptosis-signalling protein complex, apoptosis/signalling protein
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cytoplasm: Q9Y239; Ubiquitin: Cytoplasm : P0CG48
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 20713.42

構造登録者

Ver Heul, A.M.,Gakhar, L.,Piper, R.C.,Ramaswamy, S. (登録日: 2013-03-20, 公開日: 2014-03-26, 最終更新日: 2024-10-16)

主引用文献

Ver Heul, A.M.,Gakhar, L.,Piper, R.C.,Ramaswamy, S.
Crystal structure of a complex of NOD1 CARD and ubiquitin
Plos One, 9:e104017-e104017, 2014

PubMed Abstract: The Caspase Recruitment Domain (CARD) from the innate immune receptor NOD1 was crystallized with Ubiquitin (Ub). NOD1 CARD was present as a helix-swapped homodimer similar to other structures of NOD1 CARD, and Ub monomers formed a homodimer similar in conformation to Lys48-linked di-Ub. The interaction between NOD1 CARD and Ub in the crystal was mediated by novel binding sites on each molecule. Comparisons of these sites to previously identified interaction surfaces on both molecules were made along with discussion of their potential functional significance.

PubMed: 25127239
DOI: 10.1371/journal.pone.0104017

実験手法

X-RAY DIFFRACTION (2.9 Å)