4JQL

Synthesis of Benzoquinone-Ansamycin-Inspired Macrocyclic Lactams from Shikimic Acid

Summary for 4JQL

DescriptorHeat shock protein HSP 90-alpha, valerjesomycin, MAGNESIUM ION, ... (4 entities in total)
Functional Keywordsinhibitor design, hsp90, nucleotide binding domain, chaperone, geldanamycin, cytosole, chaperone-inhibitor complex, chaperone/inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm P07900
Total number of polymer chains1
Total molecular weight28547.28
Authors
Jeso, V.,Iqbal, S.,Hernandez, P.,Cameron, M.D.,Park, H.,Lograsso, P.V.,Micalizio, G.C. (deposition date: 2013-03-20, release date: 2013-04-10, Last modification date: 2013-05-22)
Primary citation
Jeso, V.,Iqbal, S.,Hernandez, P.,Cameron, M.D.,Park, H.,Lograsso, P.V.,Micalizio, G.C.
Synthesis of benzoquinone ansamycin-inspired macrocyclic lactams from shikimic Acid.
Angew.Chem.Int.Ed.Engl., 52:4800-4804, 2013
PubMed: 23554224 (PDB entries with the same primary citation)
DOI: 10.1002/anie.201301323
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.72 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.1985 0.5%0 2.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
169963
PDB entries from 2020-10-14