4JQ8

Crystal structure of EGFR kinase domain in complex with compound 4b

4JQ8 の概要

• エントリーDOI: 10.2210/pdb4jq8/pdb
• 関連するPDBエントリー: 4JQ7 4JR3 4JRV
• 分子名称: Epidermal growth factor receptor, N-[3-(4-{[(1S)-2-hydroxy-1-phenylethyl]amino}-6-phenylfuro[2,3-d]pyrimidin-5-yl)phenyl]-N~3~,N~3~-dimethyl-beta-alaninamide (3 entities in total)
• 機能のキーワード: transferase, tyrosine kinase domain, atp-binding domain, autophosphorylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37922.86

構造登録者

Peng, Y.H.,Wu, J.S. (登録日: 2013-03-20, 公開日: 2013-06-19, 最終更新日: 2023-11-08)

• 主引用文献: Peng, Y.H.,Shiao, H.Y.,Tu, C.H.,Liu, P.M.,Hsu, J.T.,Amancha, P.K.,Wu, J.S.,Coumar, M.S.,Chen, C.H.,Wang, S.Y.,Lin, W.H.,Sun, H.Y.,Chao, Y.S.,Lyu, P.C.,Hsieh, H.P.,Wu, S.Y.; Protein Kinase Inhibitor Design by Targeting the Asp-Phe-Gly (DFG) Motif: The Role of the DFG Motif in the Design of Epidermal Growth Factor Receptor Inhibitors; J.Med.Chem., 56:3889-3903, 2013; PubMed: 23611691; DOI: 10.1021/jm400072p

実験手法

X-RAY DIFFRACTION (2.83 Å)