4JQ8
Crystal structure of EGFR kinase domain in complex with compound 4b
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Epidermal growth factor receptor | polymer | 328 | 37401.3 | 1 | UniProt (P00533) Pfam (PF07714) In PDB | Homo sapiens (human) | Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1 |
| 2 | A | N-[3-(4-{[(1S)-2-hydroxy-1-phenylethyl]amino}-6-phenylfuro[2,3-d]pyrimidin-5-yl)phenyl]-N~3~,N~3~-dimethyl-beta-alaninamide | non-polymer | 521.6 | 1 | Chemie (KJ8) | |||
| 3 | water | water | 18.0 | 21 | Chemie (HOH) |
Sequence modifications
A: 672 - 997 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Gly 670 | - | expression tag |
| Pro 671 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 37401.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 521.6 | |
| All* | Total formula weight | 37922.9 |
