Voltage-gated sodium channel 1.2 C-terminal domain in complex with FGF13U and Ca2+/calmodulin

Summary for 4JPZ

DescriptorFibroblast growth factor 13, Sodium channel protein type 2 subunit alpha, Calmodulin, ... (5 entities in total)
Functional Keywordsef hand and iq motif, ion channel, membrane, transport protein
Biological sourceHomo sapiens (human)
Cellular locationCell projection, filopodium . Isoform 1: Nucleus, nucleolus. Isoform 2: Cytoplasm Q92913
Cell membrane ; Multi-pass membrane protein  Q99250
Total number of polymer chains6
Total molecular weight119317
Wang, C.,Chung, B.C.,Yan, H.,Wang, H.G.,Lee, S.Y.,Pitt, G.S. (deposition date: 2013-03-19, release date: 2014-04-16, Last modification date: 2017-11-15)
Primary citation
Wang, C.,Chung, B.C.,Yan, H.,Wang, H.G.,Lee, S.Y.,Pitt, G.S.
Structural analyses of Ca(2+)/CaM interaction with NaV channel C-termini reveal mechanisms of calcium-dependent regulation.
Nat Commun, 5:4896-4896, 2014
PubMed: 25232683 (PDB entries with the same primary citation)
DOI: 10.1038/ncomms5896
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.24760.4%3.4%0.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution