4JNC

Soluble Epoxide Hydrolase complexed with a carboxamide inhibitor

4JNC の概要

• エントリーDOI: 10.2210/pdb4jnc/pdb
• 分子名称: Bifunctional epoxide hydrolase 2, 1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide (3 entities in total)
• 機能のキーワード: epoxide hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P34913
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36543.83

構造登録者

Shewchuk, L.M. (登録日: 2013-03-15, 公開日: 2013-06-05, 最終更新日: 2023-09-20)

• 主引用文献: Thalji, R.K.,McAtee, J.J.,Belyanskaya, S.,Brandt, M.,Brown, G.D.,Costell, M.H.,Ding, Y.,Dodson, J.W.,Eisennagel, S.H.,Fries, R.E.,Gross, J.W.,Harpel, M.R.,Holt, D.A.,Israel, D.I.,Jolivette, L.J.,Krosky, D.,Li, H.,Lu, Q.,Mandichak, T.,Roethke, T.,Schnackenberg, C.G.,Schwartz, B.,Shewchuk, L.M.,Xie, W.,Behm, D.J.,Douglas, S.A.,Shaw, A.L.,Marino, J.P.; Discovery of 1-(1,3,5-triazin-2-yl)piperidine-4-carboxamides as inhibitors of soluble epoxide hydrolase.; Bioorg.Med.Chem.Lett., 23:3584-3588, 2013; PubMed: 23664879; DOI: 10.1016/j.bmcl.2013.04.019

実験手法

X-RAY DIFFRACTION (1.96 Å)