4JLF

Inhibitor resistant (R220A) substitution in the Mycobacterium tuberculosis beta-lactamase

Summary for 4JLF

• Entry DOI: 10.2210/pdb4jlf/pdb
• Related: 2GDN
• Descriptor: Beta-lactamase, PHOSPHATE ION (3 entities in total)
• Functional Keywords: beta-lactams inactivation, tuberculosis, drug design, multi drug resistance, hydrolase
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 1
• Total formula weight: 28661.46

Authors

Hazra, S.,Kurz, S.,Blanchard, J.,Bonomo, R. (deposition date: 2013-03-12, release date: 2013-10-30, Last modification date: 2023-09-20)

• Primary citation: Kurz, S.G.,Wolff, K.A.,Hazra, S.,Bethel, C.R.,Hujer, A.M.,Smith, K.M.,Xu, Y.,Tremblay, L.W.,Blanchard, J.S.,Nguyen, L.,Bonomo, R.A.; Can inhibitor-resistant substitutions in the Mycobacterium tuberculosis beta-Lactamase BlaC lead to clavulanate resistance?: a biochemical rationale for the use of beta-lactam-beta-lactamase inhibitor combinations.; Antimicrob.Agents Chemother., 57:6085-6096, 2013; PubMed: 24060876; DOI: 10.1128/AAC.01253-13

Experimental method

X-RAY DIFFRACTION (2.1 Å)