4JJR

A P21 crystal form of mammalian casein kinase 1 delta

4JJR の概要

• エントリーDOI: 10.2210/pdb4jjr/pdb
• 分子名称: Casein kinase I isoform delta (2 entities in total)
• 機能のキーワード: ck1d, kinase, casein kinase, transferase
• 由来する生物種: Mus musculus (mouse)
• 細胞内の位置: Cytoplasm (By similarity): Q9DC28
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 69452.21

構造登録者

Zeringo, N.A.,Bellizzi, J.J. (登録日: 2013-03-08, 公開日: 2013-06-12, 最終更新日: 2023-09-20)

主引用文献

Zeringo, N.A.,Murphy, L.,McCloskey, E.A.,Rohal, L.,Bellizzi, J.J.
A monoclinic crystal form of casein kinase 1 delta
Acta Crystallogr.,Sect.F, 69:1077-1083, 2013

PubMed Abstract: Casein kinase 1 δ (CK1δ) is a regulatory enzyme in the mammalian circadian oscillator and represents a potential pharmacological target for modulating circadian rhythms. Crystal structures of four different polymorphs of CK1δ have previously been determined and this article reports the crystallization and structure determination of a new crystal form belonging to space group P21. Comparison of CK1δ crystal structures reveals few conformational differences within the C-terminal lobe, but more significant movements of the β-sheet region of the N-terminal lobe were observed.

PubMed: 24100552
DOI: 10.1107/S1744309113023403

実験手法

X-RAY DIFFRACTION (2.4078 Å)