4JJP

2.06 Angstrom resolution crystal structure of phosphomethylpyrimidine kinase (thiD)from Clostridium difficile 630

Summary for 4JJP

• Entry DOI: 10.2210/pdb4jjp/pdb
• Descriptor: Phosphomethylpyrimidine kinase, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID (3 entities in total)
• Functional Keywords: idp05735, biosynthesis of cofactors, prosthetic groups, and carriers: thiamine, phosphomethylpyrimidine kinase, thid, clostridium difficile 630, virulence, pathogenesis, structural genomics, niaid, national institute of allergy and infectious diseases, center for structural genomics of infectious diseases, csgid, alpha/beta fold, transferase
• Biological source: Clostridium difficile
• Total number of polymer chains: 2
• Total formula weight: 58900.41

Authors

Halavaty, A.S.,Wawrzak, Z.,Onopriyenko, O.,Grimshaw, S.,Savchenko, A.,Anderson, W.F.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2013-03-08, release date: 2013-03-20, Last modification date: 2026-04-01)

Primary citation

Rosas-Lemus, M.,Dey, S.,Minasov, G.,Tan, K.,Anderson, S.M.,Brunzelle, J.,Nocadello, S.,Shabalin, I.,Filippova, E.,Halavaty, A.,Kim, Y.,Maltseva, N.,Osipiuk, J.,Minor, W.,Joachimiak, A.,Savchenko, A.,Anderson, W.F.,Satchell, K.J.F.
A high-throughput structural system biology approach to increase structure representation of proteins from Clostridioides difficile.
Microbiol Resour Announc, 12:e0050723-e0050723, 2023

PubMed Abstract: causes life-threatening gastrointestinal infections. It is a high-risk pathogen due to a lack of effective treatments, antimicrobial resistance, and a poorly conserved genomic core. Herein, we report 30 X-ray structures from a structure genomics pipeline spanning 13 years, representing 10.2% of the X-ray structures for this important pathogen.

PubMed: 37747257
DOI: 10.1128/MRA.00507-23

Experimental method

X-RAY DIFFRACTION (2.056 Å)