4JIB

Crystal structure of of PDE2-inhibitor complex

4JIB の概要

• エントリーDOI: 10.2210/pdb4jib/pdb
• 関連するPDBエントリー: 3ITM
• 分子名称: cGMP-dependent 3',5'-cyclic phosphodiesterase, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Isoform PDE2A3: Cell membrane ; Lipid-anchor . Isoform PDE2A2: Mitochondrion matrix . Isoform PDE2A1: Cytoplasm . Isoform 5: Mitochondrion : O00408
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 162941.29

構造登録者

Pandit, J. (登録日: 2013-03-05, 公開日: 2013-05-01, 最終更新日: 2024-02-28)

• 主引用文献: Plummer, M.S.,Cornicelli, J.,Roark, H.,Skalitzky, D.J.,Stankovic, C.J.,Bove, S.,Pandit, J.,Goodman, A.,Hicks, J.,Shahripour, A.,Beidler, D.,Lu, X.K.,Sanchez, B.,Whitehead, C.,Sarver, R.,Braden, T.,Gowan, R.,Shen, X.Q.,Welch, K.,Ogden, A.,Sadagopan, N.,Baum, H.,Miller, H.,Banotai, C.,Spessard, C.,Lightle, S.; Discovery of potent, selective, bioavailable phosphodiesterase 2 (PDE2) inhibitors active in an osteoarthritis pain model, Part I: Transformation of selective pyrazolodiazepinone phosphodiesterase 4 (PDE4) inhibitors into selective PDE2 inhibitors.; Bioorg.Med.Chem.Lett., 23:3438-3442, 2013; PubMed: 23582272; DOI: 10.1016/j.bmcl.2013.03.072

実験手法

X-RAY DIFFRACTION (1.72 Å)