4JFN

Crystal structure of the N-terminal, growth factor-like domain of the amyloid precursor protein bound to copper

4JFN の概要

• エントリーDOI: 10.2210/pdb4jfn/pdb
• 分子名称: Amyloid beta A4 protein, COPPER (II) ION, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: alzheimer's disease, gfld, app, growth factor-like domain, copper binding, metal binding protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P05067
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 18776.02

構造登録者

Wild, K.,Baumkotter, F.,Kins, S. (登録日: 2013-02-28, 公開日: 2014-07-23, 最終更新日: 2023-11-08)

• 主引用文献: Baumkotter, F.,Schmidt, N.,Vargas, C.,Schilling, S.,Weber, R.,Wagner, K.,Fiedler, S.,Klug, W.,Radzimanowski, J.,Nickolaus, S.,Keller, S.,Eggert, S.,Wild, K.,Kins, S.; Amyloid precursor protein dimerization and synaptogenic function depend on copper binding to the growth factor-like domain; J.Neurosci., 34:11159-11172, 2014; PubMed: 25122912; DOI: 10.1523/JNEUROSCI.0180-14.2014

実験手法

X-RAY DIFFRACTION (1.75 Å)