4JD9

Contact pathway inhibitor from a sand fly

Summary for 4JD9

• Entry DOI: 10.2210/pdb4jd9/pdb
• Descriptor: 14.5 kDa salivary protein, SULFATE ION (3 entities in total)
• Functional Keywords: odorant-binding protein, binding protein, glycosaminoglycan, polyphosphate, protein binding
• Biological source: Phlebotomus duboscqi (Sandfly)
• Total number of polymer chains: 7
• Total formula weight: 105866.91

Authors

Andersen, J.F.,Xu, X.,Alvarenga, P. (deposition date: 2013-02-24, release date: 2013-10-16, Last modification date: 2017-11-15)

• Primary citation: Alvarenga, P.H.,Xu, X.,Oliveira, F.,Chagas, A.C.,Nascimento, C.R.,Francischetti, I.M.,Juliano, M.A.,Juliano, L.,Scharfstein, J.,Valenzuela, J.G.,Ribeiro, J.M.,Andersen, J.F.; Novel family of insect salivary inhibitors blocks contact pathway activation by binding to polyphosphate, heparin, and dextran sulfate.; Arterioscler Thromb Vasc Biol, 33:2759-2770, 2013; PubMed: 24092749; DOI: 10.1161/ATVBAHA.113.302482

Experimental method

X-RAY DIFFRACTION (2.601 Å)