4JD9

Contact pathway inhibitor from a sand fly

Summary for 4JD9

• Entry DOI: 10.2210/pdb4jd9/pdb
• Descriptor: 14.5 kDa salivary protein, SULFATE ION (3 entities in total)
• Functional Keywords: odorant-binding protein, binding protein, glycosaminoglycan, polyphosphate, protein binding
• Biological source: Phlebotomus duboscqi (Sandfly)
• Total number of polymer chains: 7
• Total formula weight: 105866.91

Authors

Andersen, J.F.,Xu, X.,Alvarenga, P. (deposition date: 2013-02-24, release date: 2013-10-16, Last modification date: 2024-11-27)

Primary citation

Alvarenga, P.H.,Xu, X.,Oliveira, F.,Chagas, A.C.,Nascimento, C.R.,Francischetti, I.M.,Juliano, M.A.,Juliano, L.,Scharfstein, J.,Valenzuela, J.G.,Ribeiro, J.M.,Andersen, J.F.
Novel family of insect salivary inhibitors blocks contact pathway activation by binding to polyphosphate, heparin, and dextran sulfate.
Arterioscler Thromb Vasc Biol, 33:2759-2770, 2013

PubMed Abstract: Polyphosphate and heparin are anionic polymers released by activated mast cells and platelets that are known to stimulate the contact pathway of coagulation. These polymers promote both the autoactivation of factor XII and the assembly of complexes containing factor XI, prekallikrein, and high-molecular-weight kininogen. We are searching for salivary proteins from blood-feeding insects that counteract the effect of procoagulant and proinflammatory factors in the host, including elements of the contact pathway.

PubMed: 24092749
DOI: 10.1161/ATVBAHA.113.302482

Experimental method

X-RAY DIFFRACTION (2.601 Å)