4JD9

Contact pathway inhibitor from a sand fly

4JD9 の概要

• エントリーDOI: 10.2210/pdb4jd9/pdb
• 分子名称: 14.5 kDa salivary protein, SULFATE ION (3 entities in total)
• 機能のキーワード: odorant-binding protein, binding protein, glycosaminoglycan, polyphosphate, protein binding
• 由来する生物種: Phlebotomus duboscqi (Sandfly)
• タンパク質・核酸の鎖数: 7
• 化学式量合計: 105866.91

構造登録者

Andersen, J.F.,Xu, X.,Alvarenga, P. (登録日: 2013-02-24, 公開日: 2013-10-16, 最終更新日: 2024-11-27)

主引用文献

Alvarenga, P.H.,Xu, X.,Oliveira, F.,Chagas, A.C.,Nascimento, C.R.,Francischetti, I.M.,Juliano, M.A.,Juliano, L.,Scharfstein, J.,Valenzuela, J.G.,Ribeiro, J.M.,Andersen, J.F.
Novel family of insect salivary inhibitors blocks contact pathway activation by binding to polyphosphate, heparin, and dextran sulfate.
Arterioscler Thromb Vasc Biol, 33:2759-2770, 2013

PubMed Abstract: Polyphosphate and heparin are anionic polymers released by activated mast cells and platelets that are known to stimulate the contact pathway of coagulation. These polymers promote both the autoactivation of factor XII and the assembly of complexes containing factor XI, prekallikrein, and high-molecular-weight kininogen. We are searching for salivary proteins from blood-feeding insects that counteract the effect of procoagulant and proinflammatory factors in the host, including elements of the contact pathway.

PubMed: 24092749
DOI: 10.1161/ATVBAHA.113.302482

実験手法

X-RAY DIFFRACTION (2.601 Å)