4JBS

Crystal structure of the human Endoplasmic Reticulum Aminopeptidase 2 in complex with PHOSPHINIC PSEUDOTRIPEPTIDE inhibitor.

Summary for 4JBS

Entry DOI	10.2210/pdb4jbs/pdb
Related	3SE6 4E36
Descriptor	Endoplasmic reticulum aminopeptidase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-4)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
Functional Keywords	thermolysin-like catalytic domain, hydrolase, aminopeptidase, zinc binding, endoplasmic reticulum, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	227482.98
Authors	Saridakis, E.,Birtley, J.,Stratikos, E.,Mavridis, I.M. (deposition date: 2013-02-20, release date: 2013-12-11, Last modification date: 2023-09-20)
Primary citation	Zervoudi, E.,Saridakis, E.,Birtley, J.R.,Seregin, S.S.,Reeves, E.,Kokkala, P.,Aldhamen, Y.A.,Amalfitano, A.,Mavridis, I.M.,James, E.,Georgiadis, D.,Stratikos, E. Rationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responses. Proc.Natl.Acad.Sci.USA, 110:19890-19895, 2013 Cited by PubMed: 24248368 DOI: 10.1073/pnas.1309781110 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.789 Å)

Structure validation