4JBS

Crystal structure of the human Endoplasmic Reticulum Aminopeptidase 2 in complex with PHOSPHINIC PSEUDOTRIPEPTIDE inhibitor.

4JBS の概要

• エントリーDOI: 10.2210/pdb4jbs/pdb
• 関連するPDBエントリー: 3SE6 4E36
• 分子名称: Endoplasmic reticulum aminopeptidase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-4)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• 機能のキーワード: thermolysin-like catalytic domain, hydrolase, aminopeptidase, zinc binding, endoplasmic reticulum, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 227482.98

構造登録者

Saridakis, E.,Birtley, J.,Stratikos, E.,Mavridis, I.M. (登録日: 2013-02-20, 公開日: 2013-12-11, 最終更新日: 2023-09-20)

• 主引用文献: Zervoudi, E.,Saridakis, E.,Birtley, J.R.,Seregin, S.S.,Reeves, E.,Kokkala, P.,Aldhamen, Y.A.,Amalfitano, A.,Mavridis, I.M.,James, E.,Georgiadis, D.,Stratikos, E.; Rationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responses.; Proc.Natl.Acad.Sci.USA, 110:19890-19895, 2013; PubMed: 24248368; DOI: 10.1073/pnas.1309781110

実験手法

X-RAY DIFFRACTION (2.789 Å)