4JBS
Crystal structure of the human Endoplasmic Reticulum Aminopeptidase 2 in complex with PHOSPHINIC PSEUDOTRIPEPTIDE inhibitor.
4JBS の概要
エントリーDOI | 10.2210/pdb4jbs/pdb |
関連するPDBエントリー | 3SE6 4E36 |
分子名称 | Endoplasmic reticulum aminopeptidase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-4)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total) |
機能のキーワード | thermolysin-like catalytic domain, hydrolase, aminopeptidase, zinc binding, endoplasmic reticulum, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
由来する生物種 | Homo sapiens (human) |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 227482.98 |
構造登録者 | Saridakis, E.,Birtley, J.,Stratikos, E.,Mavridis, I.M. (登録日: 2013-02-20, 公開日: 2013-12-11, 最終更新日: 2023-09-20) |
主引用文献 | Zervoudi, E.,Saridakis, E.,Birtley, J.R.,Seregin, S.S.,Reeves, E.,Kokkala, P.,Aldhamen, Y.A.,Amalfitano, A.,Mavridis, I.M.,James, E.,Georgiadis, D.,Stratikos, E. Rationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responses. Proc.Natl.Acad.Sci.USA, 110:19890-19895, 2013 Cited by PubMed: 24248368DOI: 10.1073/pnas.1309781110 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.789 Å) |
構造検証レポート
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