4J8W

X-ray structure of NCP145 with chlorido(eta-6-p-cymene)(N-fluorophenyl-2-pyridinecarbothioamide)osmium(II)

Summary for 4J8W

Related4J8U 4J8V 4J8X
DescriptorHistone H3.2, Histone H4, Histone H2A, ... (9 entities in total)
Functional Keywordsnucleosomes, histone, structural protein-dna complex, structural protein/dna
Biological sourceXenopus laevis (clawed frog,common platanna,platanna)
More
Cellular locationNucleus P84233 P62799 P02281
Chromosome . Nucleus  Q6AZJ8
Total number of polymer chains10
Total molecular weight200224.18
Authors
Adhireksan, Z.,Davey, C.A. (deposition date: 2013-02-15, release date: 2013-04-17, Last modification date: 2017-11-15)
Primary citation
Meier, S.M.,Hanif, M.,Adhireksan, Z.,Pichler, V.,Novak, M.,Jirkovsky, E.,Jakupec, M.A.,Arion, V.B.,Davey, C.A.,Keppler, B.K.,Hartinger, C.G.
Novel metal(II) arene 2-pyridinecarbothioamides: a rationale to orally active organometallic anticancer agents
CHEM SCI, 4:1837-1846, 2013
DOI: 10.1039/C3SC22294B
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.41 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.26750.3%3.9%3.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution