4J8M
Aurora A in complex with CD532
Summary for 4J8M
Entry DOI | 10.2210/pdb4j8m/pdb |
Related | 4J8N |
Descriptor | Aurora kinase A, 1-[4-[[4-[(5-cyclopentyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]amino]phenyl]-3-[3-(trifluoromethyl)phenyl]urea, MAGNESIUM ION, ... (7 entities in total) |
Functional Keywords | aurora a, type ii, kinase inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome : O14965 |
Total number of polymer chains | 1 |
Total formula weight | 33339.24 |
Authors | Meyerowitz, J.G.,Gustafson, W.C.,Shokat, K.M.,Weiss, W.A. (deposition date: 2013-02-14, release date: 2014-09-10, Last modification date: 2017-11-15) |
Primary citation | Gustafson, W.C.,Meyerowitz, J.G.,Nekritz, E.A.,Chen, J.,Benes, C.,Charron, E.,Simonds, E.F.,Seeger, R.,Matthay, K.K.,Hertz, N.T.,Eilers, M.,Shokat, K.M.,Weiss, W.A. Drugging MYCN through an Allosteric Transition in Aurora Kinase A. Cancer Cell, 26:414-427, 2014 Cited by PubMed: 25175806DOI: 10.1016/j.ccr.2014.07.015 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.853 Å) |
Structure validation
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