4J7E

The 1.63A crystal structure of humanized Xenopus MDM2 with a nutlin fragment, RO5524529

4J7E の概要

• エントリーDOI: 10.2210/pdb4j7e/pdb
• 関連するPDBエントリー: 4IPF 4J3E 4J74 4J7D
• 分子名称: E3 ubiquitin-protein ligase Mdm2, [(4S,5R)-4,5-bis(4-chlorophenyl)-2,4,5-trimethyl-4,5-dihydro-1H-imidazol-1-yl]{4-[3-(methylsulfonyl)propyl]piperazin-1-yl}methanone, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: protein-protein interaction, ligase-antagonist complex, mdm2, e3 ubiquitin ligase, p53, imidazoline, nucleus, ligase/antagonist
• 由来する生物種: Xenopus laevis (clawed frog,common platanna,platanna)
• 細胞内の位置: Nucleus, nucleoplasm (By similarity): P56273
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 10624.23

構造登録者

Janson, C.,Lukacs, C.,Graves, B. (登録日: 2013-02-13, 公開日: 2013-08-07, 最終更新日: 2024-02-28)

• 主引用文献: Fry, D.C.,Wartchow, C.,Graves, B.,Janson, C.,Lukacs, C.,Kammlott, U.,Belunis, C.,Palme, S.,Klein, C.,Vu, B.; Deconstruction of a nutlin: dissecting the binding determinants of a potent protein-protein interaction inhibitor.; ACS Med Chem Lett, 4:660-665, 2013; PubMed: 24900726; DOI: 10.1021/ml400062c

実験手法

X-RAY DIFFRACTION (1.63 Å)