4J75

Crystal Structure of a parasite tRNA synthetase, product-bound

Summary for 4J75

• Entry DOI: 10.2210/pdb4j75/pdb
• Related: 4J75
• Descriptor: Tryptophanyl-tRNA synthetase, TRYPTOPHANYL-5'AMP, GLYCEROL, ... (4 entities in total)
• Functional Keywords: aminoacyl-trna synthetase, aars, trprs, parasite, protein-substrate complex, rossmann fold, translation, nucleotide binding, ligase
• Biological source: Plasmodium falciparum
• Total number of polymer chains: 2
• Total formula weight: 95684.52

Authors

Koh, C.Y.,Kim, J.E.,Verlinde, C.L.M.J.,Hol, W.G.J. (deposition date: 2013-02-12, release date: 2013-05-22, Last modification date: 2023-09-20)

• Primary citation: Koh, C.Y.,Kim, J.E.,Napoli, A.J.,Verlinde, C.L.,Fan, E.,Buckner, F.S.,Van Voorhis, W.C.,Hol, W.G.; Crystal structures of Plasmodium falciparum cytosolic tryptophanyl-tRNA synthetase and its potential as a target for structure-guided drug design.; Mol.Biochem.Parasitol., 189:26-32, 2013; PubMed: 23665145; DOI: 10.1016/j.molbiopara.2013.04.007

Experimental method

X-RAY DIFFRACTION (2.4 Å)