4J70
Yeast 20S proteasome in complex with the belactosin derivative 3e
Summary for 4J70
Entry DOI | 10.2210/pdb4j70/pdb |
Related | 1RYP 3E47 3TDD |
Related PRD ID | PRD_000915 |
Descriptor | Proteasome component Y7, Proteasome component C11, Proteasome component PRE2, ... (16 entities in total) |
Functional Keywords | proteasome, drug discovery, irreversible inhibition, beta-lactone, ntn hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Saccharomyces cerevisiae (Baker's yeast) More |
Cellular location | Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451 |
Total number of polymer chains | 28 |
Total formula weight | 729671.38 |
Authors | Kawamura, S.,Unno, Y.,List, A.,Tanaka, M.,Sasaki, T.,Arisawa, M.,Asai, A.,Groll, M.,Shuto, S. (deposition date: 2013-02-12, release date: 2013-04-17, Last modification date: 2023-09-20) |
Primary citation | Kawamura, S.,Unno, Y.,List, A.,Mizuno, A.,Tanaka, M.,Sasaki, T.,Arisawa, M.,Asai, A.,Groll, M.,Shuto, S. Potent Proteasome Inhibitors Derived from the Unnatural cis-Cyclopropane Isomer of Belactosin A: Synthesis, Biological Activity, and Mode of Action. J.Med.Chem., 56:3689-3700, 2013 Cited by PubMed: 23547757DOI: 10.1021/jm4002296 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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