4J4O

Crystal structure of FK506 binding domain of plasmodium VIVAX FKBP35 in complex with D44

Summary for 4J4O

• Entry DOI: 10.2210/pdb4j4o/pdb
• Related: 2KI3 3IHZ 3NI6 4J4N
• Descriptor: 70 kDa peptidylprolyl isomerase, putative, N-(2-ethylphenyl)-2-(3H-imidazo[4,5-b]pyridin-2-ylsulfanyl)acetamide, GLYCEROL, ... (4 entities in total)
• Functional Keywords: d44, fkbp35, fk506, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor
• Biological source: Plasmodium vivax SaI-1
• Total number of polymer chains: 1
• Total formula weight: 14652.45

Authors

Sreekanth, R.,Harikishore, A.,Yoon, H.S. (deposition date: 2013-02-07, release date: 2013-09-11, Last modification date: 2023-11-08)

Primary citation

Harikishore, A.,Niang, M.,Rajan, S.,Preiser, P.R.,Yoon, H.S.
Small molecule Plasmodium FKBP35 inhibitor as a potential antimalaria agent.
Sci Rep, 3:2501-2501, 2013

PubMed Abstract: Malaria parasite strains have emerged to tolerate the therapeutic effects of the prophylactics and drugs presently available. This resistance now poses a serious challenge to researchers in the bid to overcome malaria parasitic infection. Recent studies have shown that FK520 and its analogs inhibit malaria parasites growth by binding to FK506 binding proteins (FKBPs) of the parasites. Structure based drug screening efforts based on three-dimensional structural information of FKBPs from Plasmodium falciparum led us to identify new chemical entities that bind to the parasite FKBP35 and inhibit its growth. Our experimental results verify that this novel compound (D44) modulate the PPIase activity of Plasmodium FKBP35 and demonstrate the stage-specific growth inhibition of Plasmodium falciparum strains. Here, we present the X-ray crystallographic structures of FK506 binding domains (FKBDs) of PfFKBP35 and PvFKBP35 in complex with the newly identified inhibitor providing molecular insights into its mode of action.

PubMed: 23974147
DOI: 10.1038/srep02501

Experimental method

X-RAY DIFFRACTION (1.73 Å)