4J3D
Pseudomonas aeruginosa LpxC in complex with a hydroxamate inhibitor
Summary for 4J3D
Entry DOI | 10.2210/pdb4j3d/pdb |
Descriptor | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION, N~1~-hydroxy-N~5~-(3-hydroxypropyl)-N~2~-[4-(phenylethynyl)benzoyl]-L-glutamamide, ... (4 entities in total) |
Functional Keywords | lpxc, metalloamidase, udp-3-o-(r-3-hydroxymyristoyl)-n-acetylglucosamine deacetylase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Pseudomonas aeruginosa |
Total number of polymer chains | 2 |
Total formula weight | 66925.30 |
Authors | Lahiri, S. (deposition date: 2013-02-05, release date: 2013-04-03, Last modification date: 2024-02-28) |
Primary citation | Hale, M.R.,Hill, P.,Lahiri, S.,Miller, M.D.,Ross, P.,Alm, R.,Gao, N.,Kutschke, A.,Johnstone, M.,Prince, B.,Thresher, J.,Yang, W. Exploring the UDP pocket of LpxC through amino acid analogs. Bioorg.Med.Chem.Lett., 23:2362-2367, 2013 Cited by PubMed: 23499237DOI: 10.1016/j.bmcl.2013.02.055 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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