4J1R

Crystal Structure of GSK3b in complex with inhibitor 15R

Summary for 4J1R

• Entry DOI: 10.2210/pdb4j1r/pdb
• Descriptor: Glycogen synthase kinase-3 beta, PHOSPHATE ION, (2R)-2-(1H-indol-3-ylmethyl)-1,4-dihydropyrido[2,3-b]pyrazin-3(2H)-one, ... (5 entities in total)
• Functional Keywords: structural genomics, psi-biology, new york structural genomics research consortium, nysgrc, kinase, phosphorylation, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm : P49841
• Total number of polymer chains: 4
• Total formula weight: 190367.45

Authors

Zhan, C.,Wang, Y.,Wach, J.,Sheehan, P.,Zhong, C.,Harris, R.,Patskovsky, Y.,Bishop, J.,Haggarty, S.,Ramek, A.,Berry, K.,O'Herin, C.,Koehler, A.N.,Hung, A.W.,Young, D.W.,Almo, S.C.,New York Structural Genomics Research Consortium (NYSGRC) (deposition date: 2013-02-01, release date: 2013-03-20, Last modification date: 2023-12-06)

• Primary citation: Wang, Y.,Wach, J.,Sheehan, P.,Zhong, C.,Zhan, C.,Harris, R.,Almo, S.C.,Bishop, J.,Haggarty, S.,Ramek, A.,Berry, K.,O'Herin, C.,Koehler, A.N.,Hung, A.W.,Young, D.W.; Fragment-based approach using diversity-oriented synthesis yields a GSK3b inhibitor; To be Published,

Experimental method

X-RAY DIFFRACTION (2.702 Å)