4J1R
Crystal Structure of GSK3b in complex with inhibitor 15R
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Glycogen synthase kinase-3 beta | polymer | 424 | 47179.5 | 4 | UniProt (P49841) Pfam (PF00069) | Homo sapiens (human) | GSK-3 beta, Serine/threonine-protein kinase GSK3B |
| 2 | E, H, K, N (A, B, C, D) | PHOSPHATE ION | non-polymer | 95.0 | 4 | Chemie (PO4) | |||
| 3 | F, I, L, O (A, B, C, D) | (2R)-2-(1H-indol-3-ylmethyl)-1,4-dihydropyrido[2,3-b]pyrazin-3(2H)-one | non-polymer | 278.3 | 4 | Chemie (I5R) | |||
| 4 | G, J, M, P (A, B, C, D) | POTASSIUM ION | non-polymer | 39.1 | 4 | Chemie (K) | |||
| 5 | Q, R, S, T (A, B, C, D) | water | water | 18.0 | 95 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 420 (UniProt: P49841)
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Pro -1 | - | expression tag |
| Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 188717.9 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 1649.5 | |
| All* | Total formula weight | 190367.4 |
