4J1P

X-ray crystal structure of bromodomain 2 of human brd2 in complex with rvx208 to 1.08 A resolution

Summary for 4J1P

Entry DOI	10.2210/pdb4j1p/pdb
Related	4J3I
Descriptor	Bromodomain containing 2, isoform CRA_a, 2-[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxyquinazolin-4(3H)-one, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	brd2, bromodomain, signaling protein-inhibitor complex, signaling protein/inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	13807.88
Authors	Stein, A.J.,White, A.,Suto, R.K. (deposition date: 2013-02-01, release date: 2014-01-15, Last modification date: 2023-09-20)
Primary citation	McLure, K.G.,Gesner, E.M.,Tsujikawa, L.,Kharenko, O.A.,Attwell, S.,Campeau, E.,Wasiak, S.,Stein, A.,White, A.,Fontano, E.,Suto, R.K.,Wong, N.C.,Wagner, G.S.,Hansen, H.C.,Young, P.R. RVX-208, an Inducer of ApoA-I in Humans, Is a BET Bromodomain Antagonist. Plos One, 8:e83190-e83190, 2013 Cited by PubMed: 24391744 DOI: 10.1371/journal.pone.0083190 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.08 Å)

Structure validation