4IXH

Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Cryptosporidium parvum

Summary for 4IXH

Entry DOI	10.2210/pdb4ixh/pdb
Related	3FFS
Descriptor	Inosine-5'-monophosphate dehydrogenase, INOSINIC ACID, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	structural genomics, niaid, national institute of allergy and infectious diseases, center for structural genomics of infectious diseases, csgid, alpha-beta fold, tim barrel, oxidoreductase
Biological source	Cryptosporidium parvum More
Cellular location	Cytoplasm : Q8T6T2
Total number of polymer chains	4
Total formula weight	157366.62
Authors	Kim, Y.,Makowska-Grzyska, M.,Gu, M.,Kavitha, M.,Hedstrom, L.,Anderson, W.F.,Joachimiak, A.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2013-01-25, release date: 2013-04-03, Last modification date: 2023-09-20)
Primary citation	Gorla, S.K.,Kavitha, M.,Zhang, M.,Chin, J.E.,Liu, X.,Striepen, B.,Makowska-Grzyska, M.,Kim, Y.,Joachimiak, A.,Hedstrom, L.,Cuny, G.D. Optimization of Benzoxazole-Based Inhibitors of Cryptosporidium parvum Inosine 5'-Monophosphate Dehydrogenase. J.Med.Chem., 56:4028-4043, 2013 Cited by PubMed: 23668331 DOI: 10.1021/jm400241j PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.105 Å)

Structure validation