4IXH

Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Cryptosporidium parvum

4IXH の概要

• エントリーDOI: 10.2210/pdb4ixh/pdb
• 関連するPDBエントリー: 3FFS
• 分子名称: Inosine-5'-monophosphate dehydrogenase, INOSINIC ACID, 1,2-ETHANEDIOL, ... (5 entities in total)
• 機能のキーワード: structural genomics, niaid, national institute of allergy and infectious diseases, center for structural genomics of infectious diseases, csgid, alpha-beta fold, tim barrel, oxidoreductase
• 由来する生物種: Cryptosporidium parvum; 詳細
• 細胞内の位置: Cytoplasm : Q8T6T2
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 157366.62

構造登録者

Kim, Y.,Makowska-Grzyska, M.,Gu, M.,Kavitha, M.,Hedstrom, L.,Anderson, W.F.,Joachimiak, A.,Center for Structural Genomics of Infectious Diseases (CSGID) (登録日: 2013-01-25, 公開日: 2013-04-03, 最終更新日: 2023-09-20)

• 主引用文献: Gorla, S.K.,Kavitha, M.,Zhang, M.,Chin, J.E.,Liu, X.,Striepen, B.,Makowska-Grzyska, M.,Kim, Y.,Joachimiak, A.,Hedstrom, L.,Cuny, G.D.; Optimization of Benzoxazole-Based Inhibitors of Cryptosporidium parvum Inosine 5'-Monophosphate Dehydrogenase.; J.Med.Chem., 56:4028-4043, 2013; PubMed: 23668331; DOI: 10.1021/jm400241j

実験手法

X-RAY DIFFRACTION (2.105 Å)